Genetics Data Engineer 1

Senior Principle Data Engineer - Genetics

Your Role

You will advance our human quantitative genetics strategy by providingthe dataengineering fundamentals that enable downstream analysis. You willcollaboratewith quantitative geneticists, data scientists,data engineers, platform experts, IT, and others to ensure that data availability and quality are never the bottlenecks for our analyses.In that collaboration, you will provide the visionand implementationforhow ourFAIRdata environment works across internal and external platformssuch asbiobank trusted research environments(TREs).

You will work withother scientists to:

• Bring software tools,reference datasets, and genetic data intointernal environments.

• Bring tools, containers, and reference data into TREs (e.g., UK Biobank Research Analysis Platform, All of Us Researcher Workbench) and manage their deployment and versioning.

• Ingest andmaintainconnections to genetic reference databases (OpenTargets, GWAS Catalog,ClinVar,dbSNP, OMIM, HGMD,ChEMBL,DrugBank) and integrate them with the internal knowledge graph (Synaptix) and analytics platforms.

• Automate data QC for diverse genomic data types.

• Develop, test, and execute reproducible analysis pipelines using workflow managers and containerized environments (Docker, Singularity).

• Return resultsfrom TREsto our internal platformsin accordance witheach biobank's privacy and data protection policies.

• Optimizequery performance and pipeline execution to support rapid-turnaround target assessments and in-licensing due diligence (20-25 targets per year requiring fast genetic evaluation).

• Contribute to the design and implementation of agentic AI workflows for automated genetic evidence generation, integrating genetics pipelines with the broader agentic AI platform.

• Build andmaintaininteractive dashboards and data services that expose genetic evidence to project teams, leadership, and due diligence committees.

• Link genetic data to our AI tools and platforms, ensuring seamless data flow between genetic analyses and downstream decision-support systems. Experience building production-grade data pipelines for genetic and genomics datasets,including familiarity with common formats ( VCF, PLINK/BED/BIM/FAM/BGEN,GWAS summary statistics).

• Automate routine analyses including standard safety assessments, target-disease association lookups, and genetic evidence reports to minimize geneticist time on repetitive tasks.

• Manage cloud compute budgets andoptimizeresource usage within TREs to maximize analytical throughput withinallocatedfunding.

Who You Are

You have substantialexpertisein data engineering for scientificand genomicdata and are comfortable working both on strategic questions as well as hands-on implementation. You have

• Bachelor'sorMaster'sdegree in computer science, data engineering, bioinformatics, ora related field.

• Minimum 6 years relevant experience in data engineering, With exposure to healthcare, Medical or biological data.

• Track Record of building and deploying pipelines and solutions that show your stakeholders what is possible beyond what they had imangined or requested.

• Strong expertise in Python and Ideally R for data ingestion, processing, cleaning, and pipeline orchestration.

• Expertise in working with large, complex datasets in cloud or HPC environments, including tools such as Spark, S3, and cloud-native compute platforms (AWS, GCP, Azure). Experince with both tabular data and free text processing.

• Experience with containerization (Docker, Singularity) and infrastructure-as-code practices for reproducible deployments in secure environments.

• Solid understanding of data modeling, versioning, and reproducibilityprinciples.

• Experience with methods and requirements for medical or genetic data privacy, including data governance and controlled-access data handling.

Preferred Qualifications

• Experience withadditionalbiobank platforms or multi-ethnic datasets (e.g., Biobank Japan, Galatea,FinnGen).

• Hands on experience with biobank trsuted research enviornments such as UK Biobank ( DNAnexus), All of Us Researcher workbench, or similar platforms.

• Experience with genomis-specific tools and frameworks ( Hail, PLINK, bcftools, samtools, liftover) and workflow managers ( Nextflow, WDL, Snakemake).

• Experience building dashboards or visualization tools (e.g., Shiny, Streamlit, Plotly Dash) for scientific audiences.

• Familiarity with agentic AI Frameworks or experience building LLM-integrated data pipelines and automated reporting tools.

• Experience with API development (REST/GraphQL)and MCPfor serving analytical results to downstream applications.